Table 4.21.

Kaplan–Meier estimates of the time from onset of multiple sclerosis to the onset of irreversible disability, and of the time course of irreversible disability among 1844 patients with multiple sclerosis, according to the initial course of the disease.^a

	Relapsing–remitting onset		Progressive onset
Variable	Number of patients (n = 1562)	Median time (95% CI) in years	Number of patients (n = 282)	Median time (95% CI) in years	p valueb
Time from onset of multiple sclerosis to assignment of a score of DSS 4	1562	11.4 (10.5–12.3)	282	0.0	<0.001
Time from onset of multiple sclerosis to assignment of a score of DSS 6	1562	23.1 (20.1–26.1)	282	7.1 (6.3–7.9)	<0.001
Time from onset of multiple sclerosis to assignment of a score of DSS 7	1562	33.1 (29.2–37.0)	282	13.4 (11.0–15.9)	<0.001
Time from assignment of a score of DSS 4 to assignment of a score of DSS 6	755	5.7 (4.9–6.4)	271	5.4 (4.3–6.6)	0.74
Time from assignment of a score of DSS 4 to assignment of a score of DSS 7	755	12.1 (10.0–14.2)	271	12.0 (10.1–13.9)	0.70
Time from assignment of a score of DSS 6 to assignment of a score of DSS 7	426	3.3 (2.8–3.9)	169	4.0 (2.9–5.1)	0.48

^aKurtzke Disability Status Scale (DSS) was used to determine the extent of disability.

^bp values were calculated using the log-rank test.

Adapted from Confavreux et al (2000)

© 2006