Table 4.22.

Kaplan–Meier estimates of the time course of irreversible disability among patients with secondary progressive multiple sclerosis or with progressive disease from onset, according to the presence or absence of superimposed relapses during progression.^a

	Progressive course without superimposed relapses		Progressive course with superimposed relapses
Variable	Number of patients	Median time (95% CI) in years	Number of patients	Median time (95% CI) in years	p valueb
Secondary progressive multiple sclerosis
Time from assignment of a disability status score of 4 to assignment of a score of 6	292	4.0 (3.1–4.9)	191	4.4 (3.9–5.0)	0.68
Time from assignment of a disability status score of 4 to assignment of a score of 7	292	7.8 (6.8–8.7)	191	10.0 (7.6–12.4)	0.04
Time from assignment of a disability status score of 6 to assignment of a score of 7	223	2.6 (2.1–3.1)	133	4.3 (3.0–5.7)	0.002
Progressive multiple sclerosis from onset
Time from assignment of a disability status score of 4 to assignment of a score of 6	163	5.5 (4.5–6.5)	108	5.4 (3.3–7.5)	0.71
Time from assignment of a disability status score of 4 to assignment of a score of 7	163	12.4 (10.2–14.7)	108	11.3 (7.8–14.7)	0.65
Time from assignment of a disability status score of 6 to assignment of a score of 7	104	4.0 (2.8–5.2)	65	3.6 (2.2–5.0)	0.68

^aKurtzke Disability Status Scale was used to determine the extent of disability.

^bp values were calculated using the log-rank test.

Adapted from Confavreux et al (2000)

© 2006