Table 20-6.

Differential Diagnosis of Neonatal Diarrhea

Diagnosis	Reference(s)
Anatomic Disorders
Microvillous inclusion disease	1245
Hirschsprung’s disease	1246
Massive intestinal resection (short-bowel syndrome)	1247
Intestinal lymphangiectasis	1248
Metabolic and Enzymatic Disorders
Congenital disaccharidase deficiency (lactase, sucrase-isomaltase deficiency)	1249,1250
Congenital glucose-galactose malabsorption	1251,1252
Secondary disaccharide, monosaccharide malabsorption	337,528,1252,1253,1254,1255,1256,1257,1258
After gastrointestinal surgery
After infection
With milk-soy protein sensitivity
Cystic fibrosis	1259
Syndrome of pancreatic insufficiency and bone marrow dysfunction (Shwachman’s syndrome)	1260
Physiologic deficiency of pancreatic amylase	1261
Intestinal enterokinase deficiency	1262
Congenital bile acid deficiency syndrome	1263
Alpha/beta-lipoproteinemia	1264
Acrodermatitis enteropathica	1265,1266
Congenital chloride diarrhea	1267,1268
Primary hypomagnesemia	1269
Congenital adrenal hyperplasia	1270
Intestinal hormone hypersecretion	1271,1272
Non–beta islet cell hyperplasia (Wolman’s disease)	1273
Transcobalamin II deficiency	1274
Congenital iron storage	1275
Hartnup’s disease	1276
Congenital Na+ diarrhea	1277
Inflammatory Disorders
Cow’s milk protein intolerance	1278
Soy protein intolerance	1279,1280
Regional enteritis	1281
Ulcerative colitis	1282,1283
Primary Immunodeficiency Disorders
Wiskott-Aldrich syndrome	1284
Thymic dysplasia	1284
Acquired immunodeficiency syndrome	1285
Miscellaneous
Irritable colon of childhood (chronic nonspecific diarrhea)	1286
Phototherapy for hyperbilirubinemia	1287
Familial dysautonomia (Riley-Day syndrome)	1288
Familial enteropathy	1289,1290
High sulfates in water	1291
Phenolphthalein poisoning/child abuse	1292