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. Author manuscript; available in PMC: 2020 Apr 21.
Published in final edited form as: Clin Immunol. 2018 Jun 5;195:127–138. doi: 10.1016/j.clim.2018.06.001

Figure 6. Activation profiles of CD4+ and CD8+ T cell subsets before and after ART.

Figure 6.

Frequencies of (A) HLA-DR+CD4+ T cells and (B) HLA-DR+CD8+ T cells, in HIV-infected (pre- and post-ART; n=28; closed circles) individuals and HIV-uninfected (n=23; open circles). Blue, green, brown, red and grey represent the Naive, ED, Inter, LD and TD subsets. Data are shown as box and whisker (interquartile range) plots. Statistical significance was calculated using a Mann-Whitney U test and Wilcoxon Signed Rank test for unpaired and paired samples, respectively. Fold change in HLA-DR frequencies of (C) Naive, ED, LD and TD CD4+ T cells and (D) Naive, ED, Inter, LD and TD CD8+ T over 12 months of ART. The horizontal dotted line indicates no change from the time point prior to ART. Statistical comparisons were calculated using a one-way ANOVA test. *p < 0.05, **p < 0.01, ***p < 0.001.