Table 2.

Cannabidiol-Induced Immune Suppression by Cell Type in Human Cells In Vitro

Cell type	End-point(s)	References
PBMCs	↓rosette formation	138a
PBMCs	↓cytokines	111,112a
Human cell linesb	↓cytokines	186
HL-60b	↑apoptosis	113
Jurkat and MOLT-4 T cellsb	↑apoptosis	80a
Human coronary artery endothelial cells	↓adhesion molecules, migration, transcription factors, nitrative stress	119a
Jurkat T cellsb	↓cytokines, transcription factors	55a
Human neutrophils	↓migration	195
PBMCs	↓indoleamine-2,3-dioxygenase (IDO), ↓cytokines	142
THP-1 cellsb	↓IDO	142
PBMCs	↑apoptosis	114a
Human intestine	↓proteins and nitric oxide	96
Human liver sinusoidal endothelial cells	↓adhesion molecules	118
Human gingival mesenchymal stem cells	↓inflammatory genes	79
Caco-2 cellsb	↓phosphoproteins	82a
Primary colonic explants	↓cytokines	82a
Human neutrophils	↓ROS	185
Human PBMCs	↓proliferation and cytokines	146a
HaCaT human keratinocytesb	↓cytokines	84
Human monocytes	↑apoptosis	115a
Human plasmacytoid dendritic cells	↓CD83 expression in HIV+ dendritic cells	134a

^aDiscussed in review.

^bCell line.

ROS, reactive oxygen species.