Table 6.
Immune Enhancement by Cannabidiol
| Cell type/model | In vivo | Effect | Reference |
|---|---|---|---|
| Male human subjects | X | ↑antibody response | 213 |
| Rabbit neutrophilsa | ↑neutrophil degranulation | 181b | |
| Female Hartley guinea pigs | X | ↑skin sensitization | 214 |
| Female B6C3F1 mouse splenocytes | ↑IL-2 production | 180 | |
| Mouse BV-2 microglial cellsc | ↑chemotaxis | 182b | |
| Male Swiss mouse peritoneal macrophages | ↑IL-12 production | 187 | |
| Male Swiss mouse peritoneal macrophages | X | ↑IL-12 production (stimulated ex vivo) | 187 |
| Rat RBL-2H3 mast cellsc | ↑mast cell/basophil activation | 183b | |
| Female B6C3F1 and C57BL/6 mouse splenocytes | ↑IL-2 and IFN-γ production | 179b | |
| Female C57BL/6 mice | X | ↑LPS-induced pulmonary inflammation | 191b |
| Mouse BV-2 microglial cellsc, mouse RAW264.7 macrophage cellsc, rat HAPI microglial cellsc, male C57BL/6 microglial cells | ↑phagocytosis | 105 | |
| Female C57BL/6 splenocytes | ↑IL-2 production | 154b |
a
Sex not stated.
b
Discussed in review.
c
Cell line.