FIG. 6.

Convulsions and change in temperature caused by each cannabinoid at three doses of most. Mice were injected with 0.01 mL/g IP of each compound at the indicated dose. Activity was video-recorded and subsequently scored for the time of each convulsion as indicated by a jerk, series of jerks, and/or tonic extension of the fore and/or hindlimbs. Body temperature was measured before the injection and at 45 and 180 min after the injection and the greatest change in temperature is shown. Data shown are mean±SEM (n=4–7). Data were analyzed one drug at a time by one-way ANOVA (at p<0.05) followed by Tukey's post-test for differences between the effects of each dose. *p<0.05, **p<0.01, ****p<0.0001 versus lowest dose of same drug. ND, not determined.