Table 2.
Hormones Concentrations (Continuous and Categorical) and Odds of Thromboembolism and Hypertension
| TE (n=15) | No TE (n=2014) | Unadjusted OR* | Mediated OR*** | HTN (n=43) | No HTN (n=1863) | Unadjusted OR* | Mediated OR*** | |
|---|---|---|---|---|---|---|---|---|
| Transgender women | ||||||||
| Mean estradiola (SD) | 267.8 (305.0) | 284.4 (334.1) | 0.96 (0.80, 1.15) | 0.99 (0.84, 1.18) | 250.5 (358.9) | 286.5 (336.9) | 0.97 (0.88, 1.08) | 1.02 (0.92, 1.13) |
| 0–99 pg/mL | 33.3% (5) | 33.7% (679) | 1.86 (0.53, 6.50) | 1.34 (0.36, 4.91) | 41.9% (18) | 33.7% (629) | 1.32 (0.60, 2.93) | 0.89 (0.38, 2.08) |
| 100–200 pg/mL | 20.0% (3) | 22.0% (443) | 1.01 (0.26, 3.93) | 0.93 (0.23, 3.69) | 18.6% (8) | 21.6% (403) | 0.96 (0.41, 2.25) | 0.98 (0.40, 2.43) |
| ≥201 pg/mL | 46.7% (7) | 44.3% (892) | Ref | Ref | 39.5% (17) | 44.6% (831) | Ref | Ref |
| Mean total testosteronea (SD) | 91.8 (235.7) | 136.7 (233.2) | 0.88 (0.65, 1.19) | 0.90 (0.65, 1.25) | 166.2 (250.9) | 137.4 (233.9) | 1.04 (0.92, 1.17) | 1.16 (1.01, 1.33)# |
| <50 ng/dL (ref ≥50) | 86.7% (13) | 66.2% (1334) | 4.62 (0.91, 23.5) | 4.24 (0.82, 21.9) | 60.5% (26) | 66.2% (1234) | 0.91 (0.43, 1.90) | 0.68 (0.31, 1.49) |
| HTN (n=17) | No HTN (n=1347) | Unadjusted OR* | Mediated OR*** | |||||
|---|---|---|---|---|---|---|---|---|
| Transgender men |
||||||||
| Mean estradiola (SD) |
63.0 (24.9) |
63.7 (74.3) |
0.99 (0.50, 1.97) |
0.85 (0.29, 2.46) |
||||
| <20 pg/mL (ref ≥20) |
5.9% (1) |
2.7% (36) |
2.32 (0.30, 18.18) |
2.99 (0.33, 27.40) |
||||
| Mean total testosteronea (SD) |
579.3 (311.0) |
573.2 (350.8) |
1.00 (0.88, 1.15) |
1.05 (0.90, 1.21) |
||||
| 0–399 ng/dL |
23.5% (4) |
31.9% (429) |
0.81 (0.21, 3.06) |
0.59 (0.14, 2.51) |
||||
| 400–700 ng/dL |
47.1% (8) |
34.7% (467) |
1.51 (0.49, 4.66) |
1.60 (0.49, 5.30) |
||||
| >700 ng/dL | 29.4% (5) | 33.5% (451) | Ref | Ref | ||||
a
Model results for continuous hormone levels are presented per 100-U change in concentration.
*
All hormones are included together in the unadjusted model. ***Includes race, insurance, HIV status, age, and BMI. #p<0.05.
BMI, body mass index; HTN, hypertension; OR, odds ratio; TE, thromboembolism.