Iori 2011.

Methods	RCT; randomisation and allocation procedures not described
Participants	Age < 65 years Grade III or lower radiographic Kellgren‐Lawrence symptomatic isolated medial knee compartment osteoarthritis Failed conservative treatment Absence of additional cartilage treatment Concomitant ligamentous lesions
Interventions	I: open wedge HTO with a navigation system (n = 13; 14 knees) C: open wedge HTO without navigation system (n = 11; 13 knees)
Outcomes	Alignment (HKA angle), mechanical medial proximal tibial angle (mMPTA), mechanical lateral distal femoral angle (mLDFA), tibial slope (Brazier methods), patellar height (Insall‐Salvati Index), inferior limb length, American KSS, Modified Cincinnati Rating System Questionnaire, VAS (pain: 0 = unbearable pain and 10 = no pain)
Notes	Quote: "The authors declare that they have no conflict of interest with this study"
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	High risk	Not possible
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not described
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Quote: "All the radiological evaluations were performed by a single blinded expert radiologist"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No dropouts mentioned
Selective reporting (reporting bias)	Low risk	All outcomes presented
Other bias	Low risk	No issue