Comparison 6. EE 20 µg and gestodene 75 µg versus EE 30 µg and gestodene 75 µg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pregnancy per woman	2	799	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.23 [0.02, 2.55]
2 Discontinuation ‐ overall	2	799	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.14 [0.80, 1.63]
3 Discontinuation ‐ adverse event	3	753	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.46 [0.86, 2.46]
4 Discontinuation ‐ intermenstrual bleeding	1	64	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.0 [0.0, 0.0]
5 Discontinuation ‐ metrorrhagia	1	40	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.14 [0.00, 6.82]
6 Breakthrough bleeding ‐ cycle 3	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	6.90 [0.14, 348.82]
7 Breakthrough bleeding ‐ cycle 6	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.13 [0.00, 6.36]
8 Spotting ‐ cycle 3	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.61 [0.10, 3.66]
9 Spotting ‐ cycle 6	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.93 [0.06, 15.10]
10 Acne	2	707	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.35 [0.60, 3.08]
11 Breast tension or tenderness	3	821	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.18 [0.68, 2.05]
12 Change in libido	1	649	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.72 [0.64, 4.61]
13 Chloasma	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.93 [0.13, 6.79]
14 Depressive moods	2	707	Peto Odds Ratio (Peto, Fixed, 95% CI)	2.12 [0.80, 5.66]
15 Diarrhea	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.33 [0.05, 2.43]
16 Dizziness	2	763	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.52 [0.57, 4.02]
17 Edema	1	649	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.49 [0.09, 2.66]
18 Headache	2	707	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.98 [0.60, 1.59]
19 Nausea	2	707	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.27 [0.66, 2.45]
20 Nausea and vomiting	1	114	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.84 [0.19, 18.04]
21 Nervousness	1	649	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.51 [0.59, 3.87]
22 Varicose conditions	1	649	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.86 [0.20, 3.72]
23 Vomiting	2	707	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.68 [0.20, 2.25]
24 Weight gain >2 kg	1	452	Peto Odds Ratio (Peto, Fixed, 95% CI)	1.06 [0.63, 1.81]
25 Weight gain in kg	1	114	Mean Difference (IV, Fixed, 95% CI)	‐1.5 [‐4.23, 1.23]