Date	Event	Description
3 November 2010	New citation required but conclusions have not changed	One new trial was included (Kaunitz 2009). A secondary report (Hampton 2009) from Hampton 2001 was also added.
3 November 2010	New search has been performed	Searches were updated; searches were added for ClinicalTrials.gov and ICTRP. In the original review, 37 studies did not have eligible outcomes and were listed as 'excluded.' Under our current procedures, we would consider them 'discarded' and not list them. Hence, we removed them for brevity.
14 April 2008	Amended	Converted to new review format.
6 February 2008	New citation required and conclusions have changed	Substantive amendment
6 February 2008	New citation required but conclusions have not changed	Two new trials were found (Skouby 2005; Kluft 2006. A secondary report was identified (Burkman 2007) from an earlier trial (Hampton 2001) and the relevant data were added.
31 January 2008	New search has been performed	Searches were updated in Dec 2007 and Jan 2008.