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. 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2

Ahmed 2004.

Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women having elective CS for various reasons.

  • N = 200.


Exclusion criteria
  • Women who had received antibiotics within previous 2 weeks; had visible signs of infection; elevated temperature; allergic to the antimicrobials used.

Interventions Intervention: cephalosporin (B3).
  • Ceftriaxone.

  • 1 g single dose.

  • N = 100.


Comparison: penicillin (A4) combination.
  • Ampicillin + cloxacillin.

  • 1 g ‐ every 8 hours (3 doses).

  • N = 100.

Outcomes Post‐operative febrile morbidity; post‐operative infection; endometritis; wound infection; pelvic abscess; peritonitis; other febrile morbidity.
Notes Dates: January to June 2001
Setting: Wad Medani Teaching Hospital, Central Sudan.
Subgroups
  1. Elective CS.

  2. Before cord clamping.

  3. IV administration.

  4. Single dose cephalosporin vs multiple dose penicillin.

  • Comparisons: 1 (subgroup 2); 2; 3; 4; 10.

  • "The drugs were donated by Alhikma Company, Wad Medani, Sudan."

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “...were randomised...”
Allocation concealment (selection bias) Unclear risk “...were randomised...”
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Not blinded and the drug regimens were different, one a single dose, the other 3 doses.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No information.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up.
Selective reporting (reporting bias) Unclear risk We did not assess trial protocol.
Other bias Unclear risk No statistical differences in admission variables between the two groups. Data and P values provided on temperature, weight, gestational age, pre‐operative Hb. However, other aspects of bias unclear. · "The drugs were donated by Alhikma Company, Wad Medani, Sudan." but it seems unclear whether this might give the company any influence or not.