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. 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2

Ford 1986.

Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women undergoing CS.

  • N = 263.


Exclusion criteria
  • Women with drug allergies, antibiotics within 7 days, infection at time of enrolment, renal or hepatic dysfunction.

Interventions Intervention: cephalosporin (B2).
  • Cefoxitin.

  • 2 g; after cord clamped; plus 2 additional doses (2 g) at 4 hours apart.

  • N = 131.


Comparison: penicillin (A3).
  • Piperacillin.

  • 2 g; after cord clamped; plus 2 additional doses (2 g) at 4 hours apart.

  • N = 132.

Outcomes Febrile morbidity; duration of hospitalisation; administration of systematic antibiotics post‐operatively; wound healing; infection at operation site.
Notes Setting: UCLA Medical Center, US.
Subgroups
  1. Type of CS not defined.

  2. After cord clamping.

  3. Route of administration not specified.

  4. Multiple doses.

  • Comparison 1 (subgroup 1); 7.

  • No information on funding source of study.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “...randomly assigned...”.
Allocation concealment (selection bias) Unclear risk “...randomly assigned...”.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk Not described.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Not described.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk There appeared to be no loss to follow‐up.
Selective reporting (reporting bias) Unclear risk We did not assess trial protocol.
Other bias Unclear risk No baseline imbalances on: age; weight; duration of surgery. However, other aspects of possible bias were unclear. No information on funding source of study.