Jyothi 2010.

Methods	RCT. Individual women. 2‐arm study.
Participants	Inclusion criteria “Women who were scheduled to undergo hysterectomy for benign disease and elective cesarean delivery were enrolled in this trial”. However, only women underwent CS will be included in the review. N = 122 women having elective CS (60 having hysterectomy) Exclusion criteria “We excluded patients who gave history of hypersensitivity to penicillin or cephalosporin; or signs of pre‐existing infections and those who had received antibiotic therapy within the last seven days prior to surgery.”
Interventions	Intervention: cephalosporin (B1). Cefazolin 2 g, administered IV. Medication was administered as a single dose. Immediately after clamping the umbilical cord. Total number randomised: N = 67. Comparison: penicillin (A4) combination. Amoxycillin‐clavulanic acid 2.4 g (co‐amoxyclav) ‐ administered IV. Medication was administered as a single dose. Immediately after clamping the umbilical cord. Total number randomised: N = 55
Outcomes	Outcomes: fever and infection, endometritis. Reported outcomes: postoperative hospital stay, wound infection, asymptomatic bacteriuria, total infection, postoperative urinary infection.
Notes	Setting: Kasturba Hospital, Manipal, Karnataka, India, April 2004 to September 2005. Subgroups Elective CS. After cord clamping. Systemic ‐ IV administration. Single dose. Comparisons 1 (subgroup 2); 2; 3; 4; 6. No information about funding source for study.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information provided.
Allocation concealment (selection bias)	Unclear risk	No information provided.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information provided.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information provided.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss of follow‐up was reported.
Selective reporting (reporting bias)	Unclear risk	The study protocol is unavailable.
Other bias	Unclear risk	Baseline characteristics were similar for: age; BMI; associated disease; type of surgery (primary CS or not). Other possible biases were unclear. No information about funding source for study.