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. 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2

Lehapa 1999.

Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women who underwent emergency CS.

  • N = 233.


Exclusion criteria
  • No information provided.

Interventions Intervention: cephalosporin (B3).
  • Ceftriaxone.

  • 1 g, IV, followed by 4 × 6‐hourly doses of a placebo (physiological saline).

  • N = 108.


Comparison: penicillin (A4).
  • Ampicillin.

  • 1 g, IV, plus 4 × 6‐hourly doses of 500 mg of ampicillin.

  • N = 125.

Outcomes Abdominal and/or wound sepsis; febrile morbidity; hospital stay; antibiotic and consumable costs.
Notes Setting: Ga‐Rankuwa Hospital, South Africa.
Subgroups
  1. Non‐elective CS.

  2. Unclear when given in relation to cord clamping.

  3. IV administration.

  4. Single dose cephalosporin vs multiple doses penicillin.

  • Comparison 1 (subgroup 1); 10.

  • No information about funding source of study.


Conference abstract only.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No information provided.
Allocation concealment (selection bias) Unclear risk No information provided.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Double‐blind study.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk Double‐blind study although it is unclear whether assessors might have known allocation of not.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk None reported, but there is no information on the denominators in either group for us to be sure there was no loss of participants.
Selective reporting (reporting bias) Unclear risk We did not assess trial protocol.
Other bias Unclear risk Two groups reported as similar in baseline characteristics on: age; gestation; type of incision; length of surgery, but no data provided. Other aspects of potential bias were unclear. No information about funding source of study.