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. 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2

Lumbiganon 1994.

Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women undergoing emergency CS.

  • N = 400 but 379 analysed.


Exclusion criteria
  • No information provided.

Interventions Intervention: cephalosporin (B1).
  • Cefazolin.

  • 1g after clamping the umbilical cord.

  • N = 191.


Comparison: penicillin (A4) combination.
  • Amoxicillin plus clavulanic acid.

  • 1.2 g after clamping the umbilical cord.

  • N = 188.

Outcomes Febrile and infectious morbidity.
Notes Setting: Department of Obstetric and Gynecology, Khon Kaen University, Thailand.
Subgroups
  1. Non‐elective CS.

  2. After cord clamping.

  3. Route of administration not specified.

  4. Single dose.

  • Comparison 1 (subgroup 2); 6.

  • No information about funding source of study.

  • Conference abstract only.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk No information provided.
Allocation concealment (selection bias) Unclear risk Although the published abstract provided no information, the registration of the study with the Oxford Database of Perinatal Trials reported allocation was "by sealed, numbered envelopes" but it is unclear if these had to be used in sequential order.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk ‘Partially blinded’.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk ‘Partially blinded’.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up reported.
Selective reporting (reporting bias) Unclear risk Trial protocol not available and trial registration form only asks for principle outcomes (febrile morbidity & infectious morbidity) both of which are reported in the Conference abstract.
Other bias Unclear risk No baseline data provided and other possible biases unclear. No information about funding source of study.