Mansueto 1989.

Methods	RCT. Individual women. 2‐arm study.
Participants	Inclusion criteria Women undergoing non‐elective CS. N = 48. Exclusion criteria Allergy to penicillin or cephalosporin; impaired renal and/or liver function; fever (> 38 ºC and/or clinical signs of infection); antibiotic therapy 48 hours prior to the surgical procedure.
Interventions	Intervention: B‐lactam (F). Imipenem. 500 mg IV after cord clamped. N = 22. Comparison: cephalosporin (B3). Cefotamine. 1 g IV after cord clamped and 3 additional doses every 12 hours. N = 26.
Outcomes	Infective complications after the CS (endometritis, infection of the wound, peritonitis, urinary infections, other causes, fever morbidity).
Notes	Dates: 1 January 1988 to 30 September 1988. Setting: Umberto I Hospital, Frosinone, Italy. Subgroups Non‐elective CS. After cord clamping. Systemic ‐ IV. Single dose vs multiple doses. Comparison 14. Translated from Italian. No information about funding source of study.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Women reported to be divided randomly into two groups.
Allocation concealment (selection bias)	Unclear risk	No information.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No information.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up.
Selective reporting (reporting bias)	Unclear risk	We did not assess trial protocol.
Other bias	Unclear risk	No differences in baseline characteristics for: age, parity, length of PROM and number of vaginal examination between two groups. Other possible biases were unclear. No information about funding source of study.