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. 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2

Rosaschino 1988.

Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women having a CS.

  • N = 59.


Exclusion criteria
  • Women with certain or presumed hypersensitivity to β lactamine.

Interventions Intervention: cephalosporin (B3).
  • Ceftriaxone.

  • 1 g IV bolus; pre‐operative.

  • N = 27.


Comparison: penicillin (A3).
  • Mezlocillin.

  • 2 g IV bolus; pre‐operative.

  • N = 32.

Outcomes Tolerability, wound infections, urinary or respiratory infections, complications, side effects.
Notes Setting: Bolognini di Seriate (BG) hospital, obstetric and gynaecological clinic, Italy.
Translation: paper in Italian with summary in English. We had information extracted for us in English.
Subgroups
  1. Type of CS not defined.

  2. Before cord clamping. English abstract says preoperative, translation of main text says immediately after operation but the Italian words is 'preoperatorio'.

  3. IV administration.

  4. Single dose.

  • Comparison: 1(subgroup 1); 2 ;3; 4; 9.

  • No information about funding source of study.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomised controlled trial.
Allocation concealment (selection bias) Unclear risk No information provided.
Blinding of participants and personnel (performance bias) 
 All outcomes Unclear risk No information provided.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No information provided.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No loss to follow‐up reported.
Selective reporting (reporting bias) Unclear risk Study protocol unavailable.
Other bias Unclear risk Unable to assess other possible biases. No information about funding source of study.