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. 2014 Nov 17;2014(11):CD008726. doi: 10.1002/14651858.CD008726.pub2

Voto 1986.

Methods RCT. Individual women. 2‐arm study.
Participants Inclusion criteria
  • Women requiring a CS.

  • N = 80.


Exclusion criteria
  • None specified.

Interventions Intervention: cephalosporin (B2).
  • Cefoxitin.

  • 2 g, IV, every 4 hours, after cord clamping.

  • N = 39 with analysis on 37 (95%)


Comparison: penicillin (A4).
  • Ampicillin.

  • 2 g orally with daily doses divided into 4 doses, for 7 days.

  • N = 40 with analysis on 17 (42%).

Outcomes Analyses of cultures at endocervix, skin and tissue and urine.
Notes Setting: maternity ward, the Hospital Juan A. Fernandez, Buenos Aires, Argentina.
Translation: from Portuguese.
Subgroups
  1. Type of CS not defined.

  2. After cord clamping.

  3. IV administration of cephalosporin and oral administration of penicillin.

  4. Multiple doses.

  • We have not included data from this study because of the high loss of data from the penicillin group (58%). The authors concluded that the use of cefoxitin was efficacious in preventing infection after CS.

  • No information about funding source of study.

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk “Women were divided, at random, into two groups of which one was administered cefoxitin and the other ampicillin.”
Allocation concealment (selection bias) Unclear risk No information provided.
Blinding of participants and personnel (performance bias) 
 All outcomes High risk No blinding.
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No information provided.
Incomplete outcome data (attrition bias) 
 All outcomes High risk Of the 80 women included (GpA = 39 and GpB = 40) authors only report data on GpA = 37 and GpB = 17. Suggest loss too high and very uneven, so groups are not randomised groups. We have not used data in the meta‐analyses.
Selective reporting (reporting bias) Unclear risk The study protocol was unavailable.
Other bias Unclear risk No information on baseline characteristics and other possible biases unclear. No information about funding source of study.