| 1 Individual nadir changes in HIV‐1 RNA level |
3 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 1.1 0.5 mg/kg |
1 |
19 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.19 [‐0.42, 0.04] |
| 1.2 2 mg/kg |
1 |
19 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.81 [‐1.22, ‐0.40] |
| 1.3 5 mg/kg |
2 |
40 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.49 [‐1.65, ‐1.32] |
| 1.4 10 mg/kg |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.51 [‐1.80, ‐1.22] |
| 1.5 162 mg weekly |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.76 [‐1.14, ‐0.38] |
| 1.6 324 mg weekly |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.42 [‐1.80, ‐1.04] |
| 1.7 324 mg biweekly |
1 |
22 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.14 [‐1.67, ‐0.61] |
| 2 Changes in HIV‐1 RNA level on day 10 |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 2.1 0.5 mg/kg |
1 |
19 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.24 [‐0.61, 0.13] |
| 2.2 2 mg/kg |
1 |
19 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.91 [‐1.23, ‐0.59] |
| 2.3 5 mg/kg |
1 |
19 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.57 [‐1.91, ‐1.23] |
| 3 Changes in HIV‐1 RNA level on day 12 |
1 |
42 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.73 [‐1.91, ‐1.55] |
| 3.1 5mg/kg |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.71 [‐1.96, ‐1.46] |
| 3.2 10 mg/kg |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.75 [‐2.00, ‐1.50] |
| 4 Changes in HIV‐1 RNA level on day 22 |
1 |
64 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.87 [‐1.08, ‐0.66] |
| 4.1 162 mg weekly |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.6 [‐0.87, ‐0.33] |
| 4.2 324 mg biweekly |
1 |
22 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.05 [‐1.63, ‐0.47] |
| 4.3 324 mg weekly |
1 |
21 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.36 [‐1.76, ‐0.96] |
| 5 Antiviral response |
3 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 5.1 0.5 mg/kg |
1 |
19 |
Odds Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.11, 83.36] |
| 5.2 2 mg/kg |
1 |
19 |
Odds Ratio (M‐H, Fixed, 95% CI) |
27.44 [1.25, 601.57] |
| 5.3 5 mg/kg |
2 |
40 |
Odds Ratio (M‐H, Fixed, 95% CI) |
439.09 [25.73, 7493.14] |
| 5.4 10 mg/kg |
1 |
21 |
Odds Ratio (M‐H, Fixed, 95% CI) |
145.67 [5.30, 4004.91] |
| 5.5 162 mg weekly |
1 |
21 |
Odds Ratio (M‐H, Fixed, 95% CI) |
24.82 [1.17, 527.12] |
| 5.6 324 mg weekly |
1 |
21 |
Odds Ratio (M‐H, Fixed, 95% CI) |
147.0 [5.35, 4037.48] |
| 5.7 324 mg biweekly |
1 |
22 |
Odds Ratio (M‐H, Fixed, 95% CI) |
57.00 [2.59, 1253.22] |
| 6 No. of subjects with ≦ 400 copies/mL HIV‐1 RNA |
3 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Subtotals only |
| 6.1 0.5 mg/kg |
1 |
19 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
| 6.2 2 mg/kg |
1 |
19 |
Odds Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.11, 83.36] |
| 6.3 5 mg/kg |
2 |
40 |
Odds Ratio (M‐H, Fixed, 95% CI) |
43.99 [4.22, 459.01] |
| 6.4 10 mg/kg |
1 |
21 |
Odds Ratio (M‐H, Fixed, 95% CI) |
145.67 [5.30, 4004.91] |
| 6.5 162 mg weekly |
1 |
21 |
Odds Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.11, 82.40] |
| 6.6 324 mg biweekly |
1 |
22 |
Odds Ratio (M‐H, Fixed, 95% CI) |
5.0 [0.21, 117.21] |
| 6.7 324 mg weekly |
1 |
21 |
Odds Ratio (M‐H, Fixed, 95% CI) |
51.0 [2.30, 1129.95] |
| 7 Change in CD4 cell count on day 8 |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Subtotals only |
| 7.1 0.5 mg/kg |
1 |
19 |
Mean Difference (IV, Fixed, 95% CI) |
‐25.0 [‐100.14, 50.14] |
| 7.2 2 mg/kg |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
3.0 [‐100.64, 106.64] |
| 7.3 5 mg/kg |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
110.0 [3.14, 216.86] |
