| Methods |
Randomised, placebo‐controlled, cross‐over study |
| Participants |
8 male and 2 female participants (age of participants was not recorded) |
| Interventions |
50 mg pyridoxine or placebo given for 10 weeks followed by a 6‐week washout period and then cross‐over to the alternative treatment |
| Outcomes |
Erythrocyte aspartate aminotransferase activity to assess vitamin B6 status, PSEM to assess force generation and fatigability under ischaemic conditions |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer‐generated randomisation |
| Allocation concealment (selection bias) |
Low risk |
Pharmacy staff performed central allocation |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Both participants and observers were blinded |
| Incomplete outcome data (attrition bias)
All outcomes |
High risk |
No dropouts |
| Selective reporting (reporting bias) |
Low risk |
Outcomes specified in the protocol were reported as specified |
| Other bias |
Low risk |
No obvious other source of bias |
