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. 2014 Nov 12;2014(11):CD003458. doi: 10.1002/14651858.CD003458.pub5

MacLean 1998.

Methods Randomised, single‐blind, placebo‐controlled cross‐over trial
Participants 6 participants, 3 men (50, 39 and 27 years), 3 women (42, 29 and 25 years)
Interventions 77 mg/kg branched‐chain amino acids as a drink and a control 200 mL non‐calorific drink
Outcomes Performance on cycle ergometer for 20 minutes at maximal intensity without experiencing pain or exhaustion
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk The method of sequence generation was not described
Allocation concealment (selection bias) Unclear risk The method of allocation concealment was not described
Blinding (performance bias and detection bias) 
 All outcomes High risk Only participants were blinded. It is not clear if the placebo and treatment had the same taste
Incomplete outcome data (attrition bias) 
 All outcomes Low risk There were no dropouts or incomplete data
Selective reporting (reporting bias) Low risk There was equal reporting for placebo and treatment groups; outcomes in methods were reported as specified
Other bias Low risk No other source of bias was identified