| Methods |
Randomised, double‐blind, placebo‐controlled cross‐over trial |
| Participants |
9 cases (6 female and 3 male participants aged 9 to 61 years) |
| Interventions |
Placebo or creatine, loading dose for 5 days (150 mg/kg) then 60 mg /kg for 5 weeks then a 4‐week washout period and cross‐over to the other treatment |
| Outcomes |
Fatigue severity score, muscle 31P‐MRS, 3 minute ischaemic exercise test |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
The method of randomisation was not described |
| Allocation concealment (selection bias) |
Unclear risk |
The method for allocation concealment was not described |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
Both participants and observers were blinded |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
There were no dropouts or incomplete data |
| Selective reporting (reporting bias) |
Low risk |
Results were equally reported for both groups; outcomes specified in methods were reported as specified |
| Other bias |
Low risk |
No other source of bias identified |
