| 1 Leaving the study early: 1. Any reason |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.1 short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
0.96 [0.32, 2.88] |
| 2 Leaving the study early: 2. Due to relapse / worsening or no improvement |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 2.1 short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
0.96 [0.06, 14.43] |
| 3 Global state: 1. Change over time ‐ no better or deterioration (ITT) |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 3.1 short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
0.85 [0.40, 1.82] |
| 4 Adverse events: Movement disorders |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 4.1 dystonia ‐ short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
0.14 [0.01, 2.52] |
| 4.2 extrapyramidal signs ‐ short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
0.90 [0.62, 1.31] |
| 4.3 use of antiparkinsonian drugs ‐ short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
1.18 [0.75, 1.86] |
| 5 Other adverse events: 1. Arousal |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 5.1 drowsiness ‐ short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
1.60 [0.43, 5.93] |
| 6 Other adverse events: 2. At least one |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 6.1 short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
1.30 [1.00, 1.68] |
| 7 Other adverse events: 3. lab data |
1 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 7.1 ECG – atrial extrasystole & flattening of T‐wave in V6 ‐ short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
6.72 [0.37, 123.33] |
| 7.2 ventricular extrasystole ‐ short term |
1 |
47 |
Risk Ratio (M‐H, Random, 95% CI) |
0.32 [0.01, 7.48] |
