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. 2015 Mar 6;2015(3):CD003443. doi: 10.1002/14651858.CD003443.pub3

Comparison 28. PERPHENAZINE vs TIMIPERONE.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Leaving the study early: 1. Any reason 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.33 [0.67, 2.67]
2 Leaving the study early: 2. Due to adverse events 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1 short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.33 [0.67, 2.67]
3 Global state: 1. Change over time ‐ no better or deterioration (ITT) 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.11 [0.79, 1.55]
4 Adverse events: Movement disorders 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 akathisia ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.85 [0.56, 1.29]
4.2 dyskinesia ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.36 [0.13, 0.95]
4.3 dystonia ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.01, 8.08]
4.4 parkinsonism ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.21 [0.84, 1.73]
5 Other adverse events: 1. Anticholinergic 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 blurred vision ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 3.0 [0.12, 72.76]
6 Other adverse events: 2. Arousal 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
6.1 drowsiness ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.43 [0.57, 3.60]
6.2 excitation ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 4.75 [1.68, 13.46]
6.3 insomnia ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.31 [0.94, 1.82]
7 Other adverse events: 3. At least one 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
7.1 short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.01 [0.89, 1.16]
8 Other adverse events: 4. Cardiovascular 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
8.1 faintness, dizziness, weakness ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.5 [0.71, 3.18]
8.2 lassitude ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.07 [0.55, 2.10]
9 Other adverse events: 5. Central nervous system 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
9.1 confusion ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.67 [0.11, 3.90]
9.2 disturbance of consciousness ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 1.0 [0.06, 15.76]
9.3 dysarticulation ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.83 [0.38, 1.84]
9.4 headache ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.09, 1.19]
9.5 seizure ‐ short term 1 198 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]