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. 2015 Mar 6;2015(3):CD003443. doi: 10.1002/14651858.CD003443.pub3

Comparison 33. PERPHENAZINE vs ZUCLOPENTHIXOL.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Leaving the study early: 1. Any reason 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
1.1 short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 1.8 [0.69, 4.67]
2 Global state: 1. Change over time ‐ no better or deterioration (ITT) 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
2.1 short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 1.0 [0.07, 15.18]
3 Adverse events: Movement disorders 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
3.1 akathisia ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 1.14 [0.48, 2.71]
3.2 akinesia ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.07, 1.51]
3.3 rigidity ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 2.2 [0.88, 5.48]
3.4 tremor ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 2.2 [0.88, 5.48]
4 Other adverse events: 1. Arousal 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
4.1 excitation ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 1.29 [0.56, 2.95]
4.2 insomnia ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 0.33 [0.07, 1.51]
4.3 sleepiness/sedation ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 1.71 [0.80, 3.68]
5 Other adverse events: 2. Cardiovascular 1   Risk Ratio (M‐H, Random, 95% CI) Subtotals only
5.1 faintness, dizziness, weakness ‐ short term 1 54 Risk Ratio (M‐H, Random, 95% CI) 1.5 [0.48, 4.72]