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. 2015 Mar 6;2015(3):CD003443. doi: 10.1002/14651858.CD003443.pub3
Control Intervention Average dose (control) Studies Average dose (perphenazine)
vs Placebo to match study drug Chouinard 1975; Chouinard 1977;Collins 1967;Hanlon 1964 mean 13 mg/day
vs Aripiprazole mean 26.8 mg/day Kane 2003; Zhang 2010 mean 25.15 mg/day
vs Benperidol range 6 or 12 mg/day Eckmann 1984 range 12 or 24 mg/day
vs Bromperidol mean 6 mg/day Woggon 1978 mean 20 mg/day
vs Chlorpromazine mean 487.63 mg/day Bennett 1961; Hanlon 1965; Kurland 1961 mean 40.91 mg/day
vs Clocapramine range 75 to 150 mg/day Kurihara 1983 range 9 to 18 mg/day
vs Clopenthixol range 25 to 250 mg/day Dehnel 1968 range 8 to 80 mg/day
vs Clothiapine range 12 mg/day increased to 24 mg/day Itoh 1969 range 45 mg/day increased to 90 mg/day
vs Clozapine range 0 to 600 mg/day Sun 2000; Van Praag 1976 range 0 to 60 mg/day
vs Clozapine + perphenazine range 32 to 50 mg + 100 to 300 mg/mg/day Sun 2000 range 8 to 60 mg/day
vs Fluphenazine mean 5.92 mg/day Hanlon 1965 mean 38.61 mg/day
vs Haloperdiol range 3 to 6 mg/day Kurihara 1983 range 9 to 18 mg/day
vs Loxapine range 20 mg/day to max 150 mg/day Fruensgaard 1978 range 16 mg/day to max 120 mg/day
vs Mepazine mean 151 mg/day Bennett 1961; Kurland 1961 mean 42 mg/day
vs Methyperidol range 15 mg to 30 mg/day Itoh 1969 III range 9 mg/day to 18 mg/day
vs Olanzapine mean 16.5 mg/day CATIE 2005; Naukkarinen 2000; Wang 2008b mean 24.9 mg/day
vs Penfluridol 2 mg/day the flexible up to max 100 mg/day Itoh 1976 12 mg/day then flexible dose age up to max 60 mg/day
vs Prochlorperazine mean 59.9 mg/day Bennett 1961; Hanlon 1965; Kurland 1961 mean 40.91 mg/day
vs Quetiapine mean 401.16 mg/day CATIE 2005; Wang 2008c mean 22.65 mg/day
vs Promazine mean 438.92 mg/day Kurland 1961 mean 30.83 mg/day
vs Risperidone mean 5.3 mg/day CATIE 2005; Hoyberg 1993; Wang 2008a mean 25.4 mg/day
vs Sulpiride mean 900 mg/day Amakusa 1973; Lepola 1989 mean 20.5 mg/day
vs Thioproprazate mean 20.83 mg/day Hanlon 1965 mean 38.61 mg/day
vs Thioridazine mean 193.46 mg/day Hanlon 1965 mean 38.61 mg/day
vs Thiothixene no details Itoh 1969 II no details
vs Timiperone range 2 mg/day up to max of 12 mg/day Takahashi 1982 range 8 mg/day up to max of 48 mg/day
vs Trifluoperazine mean 11.49 mg/day Hanlon 1965 mean 38.61 mg/day
vs Trifluopromazine mean 124.13 mg/day Bennett 1961; Hanlon 1965; Kurland 1961 mean 40.9 mg/day
vs Ziprasidone mean 112.8 mg/day CATIE 2005 mean 20.8 mg/day
vs Zotepine range 75 mg/day to max 150 mg/day Imai 1980 range 12 mg/day to max 24 mg/day
vs Zuclopenthixol mean 37 mg/day Remvig 1987 mean 30 mg/day