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. 2015 Mar 6;2015(3):CD003443. doi: 10.1002/14651858.CD003443.pub3

Eckmann 1984.

Methods Allocation: randomised.
 Blindness: unclear.
 Duration: 30 days.
 Setting: hospital, single‐centre (Germany).
Participants Diagnosis: acute paranoid‐hallucinatory schizophrenia (ICD 295.3).
 N = 40.
 Age: 20 ‐ 45 years, mean ˜ 34 years.
 Sex: 16 F, 24 M.
 History: acute, inpatient.
Included: no details.
 Excluded: no details.
Consent: not stated.
Interventions 1. Perphenazine: 12 mg or 24 mg/day, n = 20.
 2. Benperidol: 6 mg or 12 mg/day, (2 patients received 9mg/day from 4th‐6th day and one of them also from 19th‐30th day), n = 20.
Additional medication: anticholinergics and sedating drugs (low potent neuroleptics, tranquillisers) as needed.
Outcomes Leaving the study early.
 Global state: no better or worse.
Unable to use ‐ 
 Mental state: BPRS end score (no SD), AMDP (no data).
 Behaviour: NOSIE end score (no SD).
 Adverse events: SAS (no data).
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomised ‐ quote: "randomisiert zugeteilt" (English: randomly allocated). No further details.
Allocation concealment (selection bias) Unclear risk Not described.
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Double‐blind: Oral liquid medication. No further details.
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk No details of people leaving early.
Selective reporting (reporting bias) High risk No means or standard deviations reported in results section.
Other bias Unclear risk Funding: no details.
Raters: not stated to be independent of treatment.