Eckmann 1984.
Methods | Allocation: randomised. Blindness: unclear. Duration: 30 days. Setting: hospital, single‐centre (Germany). | |
Participants | Diagnosis: acute paranoid‐hallucinatory schizophrenia (ICD 295.3).
N = 40.
Age: 20 ‐ 45 years, mean ˜ 34 years.
Sex: 16 F, 24 M.
History: acute, inpatient. Included: no details. Excluded: no details. Consent: not stated. |
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Interventions | 1. Perphenazine: 12 mg or 24 mg/day, n = 20.
2. Benperidol: 6 mg or 12 mg/day, (2 patients received 9mg/day from 4th‐6th day and one of them also from 19th‐30th day), n = 20. Additional medication: anticholinergics and sedating drugs (low potent neuroleptics, tranquillisers) as needed. |
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Outcomes | Leaving the study early.
Global state: no better or worse. Unable to use ‐ Mental state: BPRS end score (no SD), AMDP (no data). Behaviour: NOSIE end score (no SD). Adverse events: SAS (no data). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised ‐ quote: "randomisiert zugeteilt" (English: randomly allocated). No further details. |
Allocation concealment (selection bias) | Unclear risk | Not described. |
Blinding (performance bias and detection bias) All outcomes | Unclear risk | Double‐blind: Oral liquid medication. No further details. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | No details of people leaving early. |
Selective reporting (reporting bias) | High risk | No means or standard deviations reported in results section. |
Other bias | Unclear risk | Funding: no details. Raters: not stated to be independent of treatment. |