Itoh 1969 II.

Methods	Allocation: randomised. Blindness: double. Duration: unclear. Setting: number of participating centres unclear, Japan.
Participants	Diagnosis: schizophrenia. N = 86. Age: unclear. Sex: unclear. History: no details. Included: no details. Excluded: no details. Consent: no details.
Interventions	1. Perphenazine: no further details, n = 43. 2. Thiothixene: no further details, n = 43.
Outcomes	Leaving the study early; any reason. Global state: no better or worse. Behaviour: no better or worse. Adverse events. Unable to use ‐ Mental state: Psychiatric Rating Scale (unpublished scale).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised ‐ randomisation by numbers.
Allocation concealment (selection bias)	Unclear risk	Not clear.
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Double‐blind: no further details.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not clear.
Selective reporting (reporting bias)	Unclear risk	Not clear.
Other bias	Unclear risk	Funding: not clear. Raters: not stated to be independent of treatment.