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. 2015 Oct 27;2015(10):CD008666. doi: 10.1002/14651858.CD008666.pub3

Suharno 1993.

Methods Double‐blinded RCT.
Participants Inclusion criteria:
  • middle and low socioeconomic;

  • 16‐24 weeks pregnant;

  • 17‐35 years old;

  • parity 0‐4;

  • Hb 80‐109 g/L.

Interventions Intervention group 1: 63 women received vitamin A (2.4 mg retinol as retinyl palmitate) (equivalent to 8000 IU of vitamin A) and placebo iron tablets daily for 8 weeks.
Intervention group 2: 63 women received iron tablets (60 mg ferrous sulphate) and placebo vitamin A daily for 8 weeks.
Intervention group 3: 63 women received vitamin A and iron daily for 8 weeks.
Control group: 62 women received both placebo daily for 8 weeks.
Outcomes Maternal anaemia indices.
Notes Vitamin A levels were measured before starting supplementation.
Country: Indonesia.
Study setting: rural villages in 3 subdistricts of Bogo, West Java.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "randomly."
Allocation concealment (selection bias) Low risk 'An independent researcher randomly labelled' the preparations.
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Participants and personnel "Double blind".
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk No information given.
Incomplete outcome data (attrition bias) 
 All outcomes Low risk 54 (17%) women were excluded from the analysis: 11 moved, 23 taken supplement less than 8 weeks, 10 refused blood sample, 10 not available for 2nd blood sample.
Selective reporting (reporting bias) Unclear risk The protocol of the study is not available at the moment.
Other bias Low risk No other bias awarded.