Kochhar 1991.

Methods	Double‐blind RCT. Duration of study: 4 weeks Follow‐up: at 4 weeks
Participants	37 people with CRP, 36 cervix and 1 prostate Dx confirmed on symptoms (graded) and mucosal appearance (graded). Cumulative score
Interventions	Intervention (group 1): oral sulfasalzine 1 g tds + prednisolone enemas 20 mg bd for 4 weeks 18 people entered, 1 dropped out (unclear why), and 2 did not tolerate the drug Comparator (group 2): oral placebo + rectal sucralfate 2 g bd for 4 weeks 19 entered, with 2 dropouts (unclear why)
Outcomes	Groups' responses: 1. Clin improvement 8/15, P < 0.01; endoscopic changes 7/15, P < 0.01 2. Clin improvement 16/17, P < 0.001 (clin response better P < 0.05); endoscopic changes 12/17, P < 0.001
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, but methods of sequence generation not described
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding (performance bias and detection bias)	Low risk	Both the participants and the physician were blinded to the type of therapy
Blinding of outcome assessment subjective	Low risk	Participants were blinded, and filled out their own diary
Blinding of outcome assessment objective	Unclear risk	Not described
Incomplete outcome data: subjective outcomes	Unclear risk	Group 1: 1 drop out, reasons not discussed. 2 others dropped out because they did not tolerate the drug. Group 2: 2 drop outs, reasons not discussed
Incomplete outcome data: objective outcomes	Unclear risk	Group 1: 1 drop out, reasons not discussed. 2 others dropped out because they did not tolerate the drug. Group 2: 2 drop outs, reasons not discussed
Selective reporting (reporting bias)	Unclear risk	Study was published in 1991, so no study protocol available. However, all outcomes prespecified in the methods section were reported in the results section
Other bias	Low risk	No indications of other bias