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| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 NON ‐ Healing of fissure (persistence or recurrence) | 18 | 1315 | Odds Ratio (M‐H, Random, 95% CI) | 0.35 [0.19, 0.65] |
| 2 Headache | 17 | 1177 | Odds Ratio (M‐H, Random, 95% CI) | 4.54 [3.01, 6.85] |
