| 1 Sensitivity analysis: Excluding GTN/Placebo RCTs with very low placebo response rates (<10%): NON‐healing |
13 |
1063 |
Odds Ratio (M‐H, Random, 95% CI) |
0.49 [0.25, 0.96] |
| 2 Excluding RCT in Children with very low Placebo response rate: NON‐healing |
3 |
118 |
Odds Ratio (M‐H, Random, 95% CI) |
1.03 [0.11, 9.91] |
| 3 Excluding RCT in Adults with very low Placebo response rate: NON‐healing |
10 |
913 |
Odds Ratio (M‐H, Random, 95% CI) |
0.37 [0.17, 0.78] |
| 4 Excluding RCT with very low Placebo response rate: NON‐healing; Lignocaine |
1 |
31 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.55 [0.13, 2.31] |
| 5 Excluding study with < 10% non healing |
5 |
284 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.71 [0.42, 1.19] |
| 6 Excluding Mishra to investigate heterogeneity, Comparison 16; Medicine vs. Surgery |
14 |
939 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.10 [0.07, 0.15] |
| 7 Three Largest GTN/Placebo Studies |
3 |
636 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.11 [0.76, 1.63] |
