Ahmad 2007.
| Methods | RCT (Randomized Controlled Trial). n=50 | |
| Participants | Adults & Children. CAF (Chronic Anal Fissure) & AAF (Acute Anal Fissure) | |
| Interventions | GTN (Glyceryl TriNitrate) 0.2% bid 8 weeks vs Lidnocaine 5% bid 8 weeks | |
| Outcomes | Healing Headache Postural Hypotension Pruritis Ani |
|
| Notes | ROK (Randomization specified and acceptable) 5 Drop outs ITT + (analysis on Intention to Treat basis) 6 months F/U |
|
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | colour coded card in a thick white envelope |
| Allocation concealment (selection bias) | Low risk | A ‐ Adequate |
| Blinding (performance bias and detection bias) All outcomes | Low risk | neither patient nor examining consultant aware of treatment offered ‐ double blind |
| Selective reporting (reporting bias) | Low risk | appropriate side effects/outcomes reported |
| Other bias | Low risk | less than 10% dropout rate, ITT |
| Duration of Follow‐up 6 months or more | Low risk | 6 months follow up, |