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. 2012 Feb 15;2012(2):CD003431. doi: 10.1002/14651858.CD003431.pub3

Simpson 2003.

Methods RCT n=15
Participants CAF in children age 3‐14
Interventions GTN dosing: 0.1% & 0.05% bid 8 wk.s 
 n = 15
Outcomes healing, recurrence, headache
Notes ? f/u 0, 4 mo, 1 y. 
 AS,AC, B, SS no 
 0 drop outs
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk unclear
Allocation concealment (selection bias) Unclear risk D ‐ Not used
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk unclear
Selective reporting (reporting bias) Low risk appropriate side effects/outcomes reported
Other bias Low risk 0 drop outs,
Duration of Follow‐up 6 months or more High risk 8 weeks