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| Methods | RCT n=48 | |
| Participants | AF (Anal Fissure unspecified) | |
| Interventions | GTN 0.2% 8 weeks vs. lidocaine or placebo | |
| Outcomes | Persistence Pain relief | |
| Notes | ROK ITT ‐ | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | ROK |
| Allocation concealment (selection bias) | Low risk | A ‐ Adequate |
| Other bias | High risk | ITT‐ |
| Duration of Follow‐up 6 months or more | High risk | 8 weeks |
