Tankova 2009.

Methods	RCT n=31
Participants	CAF Adults
Interventions	ISMN 0.1% bid 6 weeks vs GTN 0.1% bid 6 weeks vs Placebo bid 6 weeks
Outcomes	Healing Headache Anal burning
Notes	AS unclear, AC unclear, B yes, SS not stated RNS ITT+ Drop‐outs 0 Follow‐up 3 months
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	unclear
Allocation concealment (selection bias)	Unclear risk	unclear
Blinding (performance bias and detection bias) All outcomes	Low risk	patient blinded but outcome assessor blinding not described
Selective reporting (reporting bias)	Low risk	appropriate side effects/ocutome reported
Other bias	Low risk	ITT+, 0 drop outs,
Duration of Follow‐up 6 months or more	High risk	3 months