Brisinda 2007.

Methods	RCT n=100
Participants	CAF (adults)
Interventions	Botox (either Botox 30u or Botox dysport 90u) vs Nitroglycerine 0.2% tid 8 weeks
Outcomes	healing incontinence headache anal burning
Notes	ROK AS ok, AC (single blinded), SS not done, 0 dropouts reported F/U 2 months ITT+
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	computer generated list in sealed envelopes
Allocation concealment (selection bias)	Unclear risk	single blinding
Blinding (performance bias and detection bias) All outcomes	Low risk	Patients were aware of the treatment but the two clinical assessors were blinded
Selective reporting (reporting bias)	Low risk	appropriate outcomes/side effects reported
Blinding of participants and personnel (performance bias) All outcomes	High risk
Blinding of outcome assessment (detection bias) All outcomes	Low risk
Duration of Follow‐up 6 months or more	High risk	follow up only 2 months