Eshghi 2007.

Methods	RCT n=60
Participants	CAF & AAF adults
Interventions	L‐Arginine 5% bid 3 months vs LIS
Outcomes	healing headache pain relief bleeding
Notes	AS not stated, AC unclear, B not blinded, SS no ITT+ RNS drop outs not stated F/U 12 weeks
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	not stated
Allocation concealment (selection bias)	Unclear risk	not stated
Blinding (performance bias and detection bias) All outcomes	High risk	not blinded
Selective reporting (reporting bias)	Low risk	appropriate outcomes/side effects reported
Other bias	Unclear risk	drop outs not stated
Duration of Follow‐up 6 months or more	High risk	12 weeks follow up,