Katsinelos 2006.

Methods	RCT n=64
Participants	CAF Adults
Interventions	Nifedipine 0.5% tid 8 week vs LIS
Outcomes	Healing Headache Flushing Anal irritation
Notes	AS adequate, AC not blinded, B no, SS not stated ITT+ ROK 1 drop outs F/U 8 weeks
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	ROK
Allocation concealment (selection bias)	Unclear risk	D ‐ Not used
Blinding (performance bias and detection bias) All outcomes	High risk	not blinded
Selective reporting (reporting bias)	Low risk	appropriate outcomes/side effects reported
Other bias	Low risk	1 drop out, ITT+,
Duration of Follow‐up 6 months or more	High risk	follow up 8 weeks