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. 2012 Feb 15;2012(2):CD003431. doi: 10.1002/14651858.CD003431.pub3

Kennedy 1999.

Methods RCT n=43
Participants CAF
Interventions GTN 0.2% 4 weeks vs placebo
Outcomes Healing 
 Pain relief 
 ARM 
 Headache
Notes ROK 
 ITT + 
 Crossovers
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk ROK
Allocation concealment (selection bias) Low risk A ‐ Adequate
Selective reporting (reporting bias) Low risk appropriate outcomes/side effects reported
Other bias Low risk ITT+
Duration of Follow‐up 6 months or more Low risk 25 months