| Methods |
RCT n=50, 25@ |
| Participants |
CAF |
| Interventions |
Botox injection either anterior or posteriorly into the internal sphincter |
| Outcomes |
Fissure healing |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Randomization Code |
| Allocation concealment (selection bias) |
Low risk |
yes |
| Blinding (performance bias and detection bias)
All outcomes |
Low risk |
double blinded |
| Selective reporting (reporting bias) |
Low risk |
|
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
yes |
| Duration of Follow‐up 6 months or more |
High risk |
2 months, then a rescue therapy for non‐healers |
