Comparison 4. Lateral wedge insole versus neutral insole.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pain (NRS)	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 Pain on walking 1 month	1	59	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.97, 0.77]
1.2 Maximum pain change with stairs 1 month	1	59	Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
1.3 Average pain at rest 12 months	1	179	Mean Difference (IV, Random, 95% CI)	‐0.4 [‐1.06, 0.26]
1.4 Pain on walking 12 months	2	224	Mean Difference (IV, Random, 95% CI)	0.10 [‐0.45, 0.65]
1.5 Maximum pain change with stairs 12 months	1	45	Mean Difference (IV, Random, 95% CI)	0.0 [‐0.58, 0.58]
2 Pain (WOMAC)	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 1 month	2	206	Mean Difference (IV, Random, 95% CI)	1.17 [‐7.69, 10.03]
2.2 3 months	1	147	Mean Difference (IV, Random, 95% CI)	5.5 [‐1.95, 12.95]
2.3 6 months	1	147	Mean Difference (IV, Random, 95% CI)	6.40 [‐0.07, 12.87]
2.4 12 months	3	358	Mean Difference (IV, Random, 95% CI)	0.89 [‐2.89, 4.67]
2.5 24 months	1	106	Mean Difference (IV, Random, 95% CI)	2.80 [‐6.12, 11.72]
3 Stiffness (WOMAC)	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 1 month	2	206	Mean Difference (IV, Random, 95% CI)	5.74 [‐0.49, 11.97]
3.2 3 months	1	147	Mean Difference (IV, Random, 95% CI)	4.20 [‐2.61, 11.01]
3.3 6 months	1	147	Mean Difference (IV, Random, 95% CI)	6.0 [‐0.48, 12.48]
3.4 12 months	3	358	Mean Difference (IV, Random, 95% CI)	0.07 [‐4.96, 5.10]
3.5 24 months	1	106	Mean Difference (IV, Random, 95% CI)	1.80 [‐7.22, 10.82]
4 Physical function (WOMAC)	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 1 month	2	206	Mean Difference (IV, Random, 95% CI)	2.47 [‐2.49, 7.44]
4.2 3 months	1	147	Mean Difference (IV, Random, 95% CI)	5.20 [‐0.94, 11.34]
4.3 6 months	1	147	Mean Difference (IV, Random, 95% CI)	6.0 [‐0.48, 12.48]
4.4 12 months	3	358	Mean Difference (IV, Random, 95% CI)	0.94 [‐2.98, 4.87]
4.5 24 months	1	106	Mean Difference (IV, Random, 95% CI)	‐0.40 [‐9.47, 8.67]
5 Health‐related quality of life	1	179	Mean Difference (IV, Random, 95% CI)	0.0 [‐0.06, 0.06]
6 Physical activity scale for the elderly	1	179	Mean Difference (IV, Random, 95% CI)	15.0 [‐8.45, 38.45]
7 Number of steps taken per day	1	179	Mean Difference (IV, Random, 95% CI)	1371.0 [38.53, 2703.47]
8 Global patient assessment at 24 months	1	106	Mean Difference (IV, Random, 95% CI)	1.60 [‐7.41, 10.61]
9 Compliance at 6 months	1	156	Risk Ratio (M‐H, Random, 95% CI)	1.18 [1.01, 1.38]
10 Time for negotiation of stairs	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
10.1 1 month	1	59	Mean Difference (IV, Random, 95% CI)	1.10 [‐1.18, 3.38]
10.2 12 months	1	45	Mean Difference (IV, Random, 95% CI)	‐0.30 [‐3.06, 2.46]
11 6‐Minute walk distance	1		Mean Difference (IV, Random, 95% CI)	Subtotals only
11.1 1 month	1	59	Mean Difference (IV, Random, 95% CI)	23.00 [‐18.61, 64.61]
11.2 12 months	1	45	Mean Difference (IV, Random, 95% CI)	‐25.20 [‐77.37, 26.97]