Comparison 1. Prophylactic gastrojejunostomy for unresectable periampullary carcinoma.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Survival	2		Hazard Ratio (Fixed, 95% CI)	1.02 [0.84, 1.25]
2 Peri‐operative morbidity	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Peri‐operative mortality	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	2.43 [0.10, 57.57]
2.2 Cholangitis	1	87	Risk Ratio (M‐H, Fixed, 95% CI)	1.95 [0.38, 10.12]
2.3 Bile leak	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.29, 5.27]
2.4 Gastroenteral leak	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	0.81 [0.05, 12.33]
2.5 Delayed gastric emptying	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	2.99 [0.63, 14.23]
2.6 Wound infection	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	3.19 [0.55, 18.59]
2.7 Chest complications	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	0.44 [0.08, 2.34]
2.8 Cardiac complications	1	65	Risk Ratio (M‐H, Fixed, 95% CI)	1.61 [0.32, 8.19]
3 Quality of life			Other data	No numeric data
4 Gastric outlet obstruction	2	152	Risk Ratio (M‐H, Fixed, 95% CI)	0.10 [0.03, 0.37]
5 Operating time	1	87	Mean Difference (IV, Fixed, 95% CI)	45.0 [21.39, 68.61]
6 Hospital stay	2	152	Mean Difference (IV, Fixed, 95% CI)	0.97 [‐0.18, 2.12]