OR RE Model	Standard Dose Model Median (95% CI)	Unadjusted Model Median (95% CI)	Dose Adjusted Model Median (95% CI)
Abatacept	1.25 (0.72 to 2.15)	1.10 (0.73 to 1.66)	1.24 (0.74 to 2.07)
Adalimumab	1.03 (0.67 to 1.54)	1.04 (0.75 to 1.45)	0.86 (0.51 to 1.44)
Anakinra	1.44 (0.80 to 2.68)	1.19 (0.74 to 1.92)	1.38 (0.79 to 2.41)
Certolizumab	1.17 (0.71 to 1.95)	1.18 (0.77 to 1.80)	1.17 (0.74 to 1.88)
Etanercept	1.38 (0.80 to 2.46)	1.13 (0.71 to 1.81)	1.20 (0.71 to 2.06)
Golimumab	1.24 (0.78 to 1.98)	1.18 (0.81 to 1.69)	1.15 (0.74 to 1.79)
Infliximab	1.55 (1.01 to 2.35)*	1.54 (1.17 to 2.03)*	1.45 (0.98 to 2.11)
Rituximab	1.54 (0.49 to 4.63)	1.49 (0.94 to 2.40)	1.28 (0.49 to 3.37)
Tocilizumab	1.31 (0.57 to 3.01)	1.34 (0.85 to 2.10)	1.11 (0.53 to 2.28)
Overall	1.28 (1.09 to 1.50)*
Data points Residual deviance DIC	(101) 113 642.73	(160) 178.4 1012.58	(163) 175.9 1016.75