Comparison	Standard Dose Model OR (95% CI)	Unadjusted Dose Model OR (95% CI)	Dose Adjusted Model OR (95% CI)
Adalimumab vs Etanercept	1.04 (0.51 to 2.02)	0.86 (0.48 to 1.49)	1.02 (0.53 to 1.91)
Certolizumab vs Etanercept	1.02 (0.44 to 2.32)	0.98 (0.49 to 1.96)	0.96 (0.44 to 2.08)
Golimumab vs Etanercept	1.03 (0.41 to 2.514)	1.07 (0.51 to 2.19)	0.94 (0.40 to 2.20)
Abatacept vs Etanercept	0.90 (0.38 to 2.10)	0.90 (0.45 to 1.75)	0.76 (0.33 to 1.75)
Infliximab vs Etanercept	1.81 (0.89 to 3.68)	1.72 (1.02 to 2.91)*	1.69 (0.89 to 3.20)
Rituximab vs Etanercept	2.11 (0.30 to 22.43)	1.87 (0.90 to 3.94)	1.31 (0.27 to 6.47)
Anakinra vs Etanercept	1.26 (0.45 to 3.34)	1.21 (0.52 to 2.82)	1.19 (0.47 to 3.01)
Tocilizumab vs Etanercept	1.41 (0.43 to 4.53)	1.09 (0.52 to 2.28)	1.15 (0.41 to 3.13)
Certolizumab vs Adalimumab	0.98 (0.43 to 2.33)	1.14 (0.57 to 2.33)	0.95 (0.44 to 2.12)
Golimumab vs Adalimumab	1.00 (0.40 to 2.49)	1.24 (0.59 to 2.58)	0.93 (0.39 to 2.22)
Abatacept vs Adalimumab	0.87 (0.37 to 2.09)	1.05 (0.52 to 2.08)	0.75 (0.32 to 1.76)
Infliximab vs Adalimumab	1.74 (0.86 to 3.70)	2.00 (1.17 to 3.49)*	1.66 (0.87 to 3.23)
Rituximab vs Adalimumab	2.04 (0.30 to 22.18)	2.17 (1.04 to 4.74)*	1.29 (0.26 to 6.55)
Anakinra vs Adalimumab	1.21 (0.44 to 3.32)	1.41 (0.61 to 3.32)	1.17 (0.46 to 3.03)
Tocilizumab vs Adalimumab	1.36 (0.42 to 4.43)	1.27 (0.60 to 2.69)	1.14 (0.41 to 3.15)
Golimumab vs Certolizumab	1.01 (0.35 to 2.78)	1.09 (0.46 to 2.51)	0.97 (0.37 to 2.57)
Abatacept vs Certolizumab	0.88 (0.33 to 2.31)	0.91 (0.40 to 2.03)	0.79 (0.30 to 2.05)
Infliximab vs Certolizumab	1.77 (0.75 to 4.22)	1.75 (0.89 to 3.47)	1.75 (0.79 to 3.84)
Rituximab vs Certolizumab	2.07 (0.28 to 23.37)	1.89 (0.82 to 4.55)	1.36 (0.26 to 7.27)
Anakinra vs Certolizumab	1.23 (0.40 to 3.65)	1.24 (0.48 to 3.16)	1.24 (0.44 to 3.46)
Tocilizumab vs Certolizumab	1.39 (0.39 to 4.85)	1.11 (0.47 to 2.60)	1.20 (0.39 to 3.59)
Abatacept vs Golimumab	0.87 (0.31 to 2.48)	0.84 (0.37 to 1.94)	0.81 (0.30 to 2.24)
Infliximab vs Golimumab	1.75 (0.70 to 4.53)	1.62 (0.79 to 3.34)	1.80 (0.76 to 4.28)
Rituximab vs Golimumab	2.05 (0.27 to 24.09)	1.76 (0.73 to 4.30)	1.38 (0.26 to 7.74)
Anakinra vs Golimumab	1.22 (0.38 to 3.90)	1.14 (0.44 to 3.02)	1.27 (0.43 to 3.81)
Tocilizumab vs Golimumab	1.36 (0.37 to 5.12)	1.03 (0.43 to 2.49)	1.23 (0.38 to 3.95)
Infliximab vs Abatacept	2.01 (0.87 to 4.77)	1.92 (1.01 to 3.71)*	2.21 (0.98 to 5.09)
Rituximab vs Abatacept	2.35 (0.32 to 26.5)	2.07 (0.91 to 4.92)	1.72 (0.32 to 9.40)
Anakinra vs Abatacept	1.40 (0.45 to 4.32)	1.35 (0.53 to 3.47)	1.57 (0.53 to 4.68)
Tocilizumab vs Abatacept	1.57 (0.44 to 5.65)	1.22 (0.53 to 2.84)	1.51 (0.47 to 4.78)
Rituximab vs Infliximab	1.16 (0.17 to 12.87)	1.09 (0.53 to 2.26)	0.78 (0.16 to 3.85)
Anakinra vs Infliximab	0.70 (0.24 to 1.91)	0.71 (0.31 to 1.60)	0.71 (0.28 to 1.80)
Tocilizumab vs Infliximab	0.78 (0.24 to 2.54)	0.64 (0.31 to 1.30)	0.68 (0.24 to 1.88)
Anakinra vs Rituximab	0.59 (0.05 to 4.61)	0.65 (0.24 to 1.68)	0.91 (0.16 to 5.16)
Tocilizumab vs Rituximab	0.67 (0.05 to 5.67)	0.59 (0.24 to 1.40)	0.88 (0.15 to 5.20)
Tocilizumab vs Anakinra	1.12 (0.29 to 4.49)	0.90 (0.34 to 2.41)	0.97 (0.28 to 3.22)