Database searched	Search strategy
The Cochrane Database of Systematic Reviews	#1 ( (best in All Text near/3 support* in All Text) or (optim* in All Text near/3 support* in All Text) or (support* in All Text near/3 care* in All Text) or (support* in All Text near/3 caring in All Text) ) #2 MeSH descriptor GASTROINTESTINAL NEOPLASMS explode all trees #3 ( (gastrointestinal in All Text or gastro‐intestinal in All Text or (esophageal in All Text and oesophageal in All Text) or pancrea* in All Text or gastric in All text or stomach in All Text or intestin* in All Text or cecal in All Text or appendiceal in All Text or colorectal in All Text or colonic in All Text or sigmoid in All Text or rectal in All Text or anus in All Text or "anal gland" in All Text) and (neoplasm* in All Text or cancer* in All Text or tumor* in All Text or tumour* in All Text or carcinoma* in All Text or malignan* in All Text or metastas* in All Text) ) #4 MeSH descriptor PANCREATIC NEOPLASMS explode all trees #5 (#2 or #3 or #4) #6 (#1 and #5)
Cochrane Sensitive Search strategy for RCTs	1. randomized controlled trial.pt. 2. controlled clinical trial.pt. 3. randomized controlled trials.sh. 4. random allocation.sh. 5. double blind method.sh. 6. single blind method.sh. 7. or/1‐6 8. (ANIMALS not HUMAN).sh. 9. 7 not 8 10. clinical trial.pt. 11. exp clinical trials/ 12. (clin$ adj25 trial$).ti,ab. 13. ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab. 14. placebos.sh. 15. placebo$.ti,ab. 16. random$.ti,ab. 17. research design.sh. 18. or/10‐17 19. 18 not 8 20. 19 not 9 21. 9 or 19
EMBASE via Ovid	1. ((best adj3 support$) or (optim$ adj3 support$) or (support$ adj3 care$) or (support$ adj3 caring) or (supportive adj3 treatment$)).mp. [mp=title, subject heading word, abstract, instrumentation] 2. Gastrointestinal Tumor/ or Gastrointestinal Stromal Tumor/ 3. exp Pancreas Tumor/ 4. ((gastrointestinal or gastro‐intestinal or esophageal or oesophageal or pancrea$ or gastric or stomach or intestin$ or cecal or appendiceal or colorectal or colonic or sigmoid or rectal or anus or "anal gland") and (neoplasm$ or cancer$ or tumor$ or tumour$ or carcinoma$ or malignan$ or metastas$)).mp. [mp=title, subject heading word, abstract, instrumentation] 5. or/2‐4 6. 1 and 5
The above subject search was linked to the following Filter for EMBASE via OVID	1. random$.ti,ab. 2. factorial$.ti,ab. 3. (crossover$ or cross over$ or cross‐over$).ti,ab. 4. placebo$.ti,ab. 5. (doubl$ adj blind$).ti,ab. 6. (singl$ adj blind$).ti,ab. 7. assign$.ti,ab. 8. allocat$.ti,ab. 9. volunteer$.ti,ab. 10. CROSSOVER PROCEDURE.sh. 11. DOUBLE‐BLIND PROCEDURE.sh. 12. RANDOMIZED CONTROLLED TRIAL.sh. 13. SINGLE BLIND PROCEDURE.sh. 14. or/1‐13 15. ANIMAL/ or NONHUMAN/ or ANIMAL EXPERIMENT/ 16. HUMAN/ 17. 16 and 15 18. 15 not 17 19. 14 not 18
CINAHL Search Strategy (As MEDLINE)	1. Random Assignment/ 2. single‐blind studies/ 3. Double‐Blind Studies/ 4. Triple‐Blind Studies/ 5. Crossover Design/ 6. Factorial Design/ 7. (multicentre study or multicenter study or multi‐centre study or multi‐center study).mp. [mp=title, cinahl subject headings, abstract, instrumentation] 8. random$.ti,ab. 9. latin square.ti,ab. 10. cross‐over.mp. or crossover.ti,ab. [mp=title, cinahl subject headings, abstract, instrumentation] 11. Placebos/ 12. ((singl$ or doubl$ or trebl$ or tripl$) adj25 (blind$ or mask$)).ti,ab. 13. placebo$.mp. [mp=title, cinahl subject headings, abstract, instrumentation] 14. Clinical Trials/ 15. (clin$ adj25 trial$).mp. [mp=title, cinahl subject headings, abstract, instrumentation] 16. or/1‐15
PsycINFO Search Strategy	1. ((best adj3 support$) or (optim$ adj3 support$) or (support$ adj3 care$) or (support$ adj3 caring) or (supportive adj3 treatment$)).mp. [mp=title, abstract, heading word, table of contents, key concepts] 2. ((gastrointestinal or gastro‐intestinal or esophageal or oesophageal or pancrea$ or stomach or intestin$ or cecal or appendiceal or colorectal or colonic or sigmoid or rectal or anus or "anal gland") and (neoplasm$ or cancer$ or tumor$ or tumour$ or carcinoma$ or malignan$ or metastas$)).mp. [mp=title, abstract, heading word, table of contents, key concepts] 3. 1 and 2