Zollweg 1997.

Methods	Randomised controlled trial. Randomised using a random numbers table Blinding: investigators and outcomes assessors blinded Duration: 9 months
Participants	Diagnosis: cognitive impairment including autism spectrum disorder. Age: 7‐24 years n=30
Interventions	1. AIT 2 30 min sessions for 10 consecutive days 2. Control: as above but music unmodified
Outcomes	Standardised tests of behaviour, sound sensitivity, measurement of pure tone thresholds
Notes	28 analysed for ABC at 9mths 22 analysed for loudness discomfort 14 analysed for pure tone thresholds
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random numbers table
Allocation concealment (selection bias)	High risk	Inadequate, following communication with study author (Zollweg 2002 (pers comm))
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	2 patients lost to follow‐up (1 from each group) prior to completion of study. There were fewer participants for audiological and sound sensitivity data due to illness or poor cooperation
Selective reporting (reporting bias)	Low risk	The outcomes listed in the methods are reported in the results
Other bias	Unclear risk	Treatment group included 9 cognitively impaired and 6 autistic patients, control group included 12 cognitively impaired and 3 autistic patients. Correspondence with author confirmed that all participants had been diagnosed with autism
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Investigators blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcomes assessors blinded