Mudford 2000.

Methods	Randomised controlled trial (cross‐over) Methods: geographically divided into groups, then into subgroups alphabetically by the first letter of their name Blinding: investigators and outcomes assessors Duration: 14mths
Participants	Diagnosis: autism (DSM4 or ICD10) Age: 5.75‐13.92 years n=16
Interventions	1. AIT: 2 30min sessions for 10 consecutive days 2. Control: as above, but headphones non‐functional and unmodified music played in the room (not through AIT device)
Outcomes	Standardised tests assessing behaviour, language and cognitive ability, parental reports, observations by investigators
Notes	5 lost to follow‐up due to lack of cooperation, safety issues, transport problems
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Participants geographically divided into groups, then into subgroups alphabetically by the first letter of their name
Allocation concealment (selection bias)	High risk	Inadequate, following communication with the author (Mudford 2002 (pers comm))
Incomplete outcome data (attrition bias) All outcomes	High risk	5 of 21 participants (24%) lost to follow‐up due to lack of cooperation, safety issues, transport problems
Selective reporting (reporting bias)	Low risk	Pre‐specified outcomes described in methods are reported in results
Other bias	Low risk	Funded by a research grant from National Health Service Research and Development Programme for People with Physical and Complex Disabilities. Treatment providers (who assisted with the study) from Honormead Schools have ceased to provide auditory integration training
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Investigators blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Outcomes assessors blinded