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. Author manuscript; available in PMC: 2020 Apr 21.
Published in final edited form as: Anal Chem. 2020 Feb 24;92(6):4427–4435. doi: 10.1021/acs.analchem.9b05364

Figure 1.

Figure 1.

The LC-IMS-MS instrumentation and spectra utilized in this manuscript. (A) The instrumental schematic for the DTIMS-QTOF MS platform used in this work (Agilent 6560). (B) The RPLC-IMS-MS workflow designed to separate and characterize PFAS isomers and subclasses. The RPLC, IMS and MS stages are illustrated separately along with their corresponding mechanisms for structural discrimination. (C) The IMS drift time profiles possible for isobaric and isomeric separations. Deprotonated ions for 6:2 FTS and Hydro-EVE are illustrated along with their resolution in a mixture. (D) The drift time aligned MS/MS fragments of the 6:2 FTS and Hydro-EVE isobars illustrating the different components for each molecule and their distinction with IMS at 5V CID energy and mass selection of precursor ion 426.9 m/z (asterisk).